3-Dibenzyl Phosphono
Key intermediate in antiviral nucleotide analogue synthesis
Technical / Structural Monograph
3-Dibenzyl Phosphono is an organophosphorus reagent featuring protective benzyl ester structures. It is widely valued in antiviral nucleotide chemistry for its robust chemical stability, ease of selective deprotection under mild conditions, and excellent kinetic properties during coupling reactions.
Synthesis Role & End-Use Applications
A highly versatile organophosphorus intermediate widely used in medicinal organic synthesis, particularly for the development of advanced antiviral and anticancer phosphonate-linked API prodrugs.
Typical Quality Specification
| Test Parameter | Specification | Method |
|---|---|---|
| Appearance | Clear to pale yellow viscous liquid or white to off-white solid | — |
| Purity | ≥97.0% | GC/HPLC |
| Assay / Purity | ≥97.0% | GC/HPLC |
| Single Maximum Impurity | < 0.1% | — |
| Total Impurities | < 0.5% | — |
| Heavy Metals | < 10 ppm | — |
| Sulfated Ash | < 0.1% | — |
Packaging & Storage
High-integrity, secure HDPE bottles with induction seal liners
Store at refrigerated temperature 2-8°C preferred for long-term stability
36 months when stored strictly under recommended refrigeration parameters